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EGCG × Neem — Oral Cancer Chemoprevention

One project, every layer connected — objectives, literature, hypotheses, experiments, IP and publications with version control and collaboration.

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StageExperimentprotocol ready
EvidenceStrong
Collaborators42 PIs · 1 lab
Versionv7updated today

Objectives

1
Establish combination synergy
Quantify EGCG+Neem CI in OSCC lines.
2
Validate in-vivo
DMBA hamster tumour-burden reduction.
3
Secure IP + publish
Oral-film patent + Phytomedicine submission.

Linked modules

📚 Literature🧭 Gaps💡 Hypotheses🧪 Experiment🕸 Graph⚖ Patent
42 curated papers · 5 clusters · 7 contradictions tracked. Open Literature Intelligence →
◆
EGCG apoptosis in OSCC (2023)
Core support · cited in H1.
◆
Nimbolide NF-κB suppression (2021)
Mechanistic anchor.
H1 · Dual Nrf2/NF-κB modulation
Novelty 0.86 · open →
H2 · Nano-EGCG bioavailability
Novelty 0.81
Protocol v3 · DMBA hamster, 5 arms, 14 wk, powered n=12. Open protocol →
RandomisedBlindedEthics pending
Manuscript draft · readiness 78 · target Phytomedicine (IF 7.9). Open Publication Intelligence →
Lead: EGCG+Neem oral film · novelty 0.88 · FTO clear. Open Patent Intelligence →
v7
Protocol stats updated
Today · Dr. Badhe
v6
H1 counter-evidence added
2 days ago · A. Rao (PI)
v5
Patent lead promoted
4 days ago · Dr. Badhe

Team

PB
Dr. P. Badhe
Owner · PI
AR
A. Rao
Co-PI · approve rights
SL
Swalife Lab
Collaborator

Security

🔒 EncryptedAudit log onInstitution accountIP protected

Approval workflow: changes to protocols require Co-PI sign-off.

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